In 2022, the Microbiome Research group made significant progress in understanding the human microbiome in relation to both health and inflammatory bowel diseases. They also investigated the impact of probiotics on the modulation of gut microbiota. Furthermore, they established one of the most comprehensive databases for studying fungi in the human microbiome. Additionally, the group proposed the microbiome as a potential indicator of COVID-19 severity in critically ill patients. These research endeavors align with two key topics of the Institute: “Global Health” and “Personalized Medicine, Innovative Diagnostics.”The group successfully secured a postdoctoral fellowship through the Sara Borell Program (CD22/00177). They have also published five papers as primary authors, all in quartile 1. One doctoral candidate defended her thesis under the group’s supervision. Recognizing their research achievements, the group received funding from la Generalitat de Catalunya (2021 SGR 00459).

Group Leader
Chaysavanh Manichanh

PhD Students
Zixuan Xie, Zaida Soler, Luis Mayorga, Gerard Serrano, Silvia Cuenca, Estela Rosell

Nursing and Technical Staff
Sara Vega, Alejandra Gonzalez, Marc Pons, Andrea Martinez










Cuenca S, Soler Z, Serrano-Gómez G, Xie Z, Barquinero J, Roca J, Sirvent JM, Manichanh C.
Dysbiosis: An Indicator of COVID-19 Severity in Critically Ill Patients
Int J Mol Sci. 2022 Dec 13;23(24):15808
DOI: doi: 10.3390/ijms232415808
IF: 6.208

Vargas M, Yañez F, Elias A, Bernabeu A, Goya M, Xie Z, Farrás A, Sánchez O, Soler Z, Blasquez C, Valle L, Olivella A, Muñoz B, Brik M, Carreras E, Manichanh C
Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes
Acta Obstet Gynecol Scand. 2022 Dec;101(12):1403-1413
DOI: doi: 10.1111/aogs.14460
IF: 4.544

Mayorga L, Serrano-Gómez G, Xie Z, Borruel N, Manichanh C
Intercontinental Gut Microbiome Variances in IBD
Int J Mol Sci. 2022 Sep 17;23(18):10868
DOI: doi: 0.3390/ijms231810868
IF: 6.208

Xie Z, Manichanh C
FunOMIC: Pipeline with built-in fungal taxonomic and functional databases for human mycobiome profiling
Comput Struct Biotechnol J. 2022 Jul 11;20:3685-3694
DOI: doi: 10.1016/j.csbj.2022.07.010
IF: 6.155

Oyarzun I, Le Nevé B, Yañez F, Xie Z, Pichaud M, Serrano-Gómez G, Roca J, Veiga P, Azpiroz F, Tap J, Manichanh C
Human gut metatranscriptome changes induced by a fermented milk product are associated with improved tolerance to a flatulogenic diet
Comput Struct Biotechnol J. 2022 Apr 5;20:1632-1641
DOI: doi: 10.1016/j.csbj.2022.04.001
IF: 6.155

Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections
Principal Investigator: Chaysavanh Manichanh
Agency: European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Action, Innovative Training Network
Funding: 250,940 €
Period: 2019-2022

Inflammatory Bowel Disease and Microbiome: Diagnosis and prediction of disease activity from the lab to the patients
Principal Investigator: Chaysavanh Manichanh
Agency: Instituto de Salud Carlos III
Funding: 135,520 €
Period: 2021-2023