Our group has continued to work mainly on the study of biomarkers that favour the occurrence of epileptic seizures and those associated with poorer cognitive performance. This year, the group has obtained a new competitive grant from the Fundación Eugenio Rodríguez Pascual for the study of biomarkers related to epilepsy in subarachnoid haemorrhage, as well as 2 predoctoral fellowships (Aula VH and Carles Margarit), which will help to further strengthen the different research lines of the team. In 2022, the group published 12 articles in indexed journals and presented its work at national and international congresses (27 communications). In addition, it continues to be one of the groups with the highest recruitment in international epilepsy clinical trials, currently participating in 12 of them.

Group Leader
Estevo Santamarina Pérez

Principal Investigator (PI)
Manuel Toledo Argany, Laura Abraira del Fresno, Elena Fonseca Hernández

PhD Students
Daniel Campos Fernández, Sofía Lallana Serrano

Nursing and Technical Staff
Manuel Quintana Luque, Javier Sánchez López, Enric Bellido Castillo










Restrepo-Vera JL, Coscojuela P, Fonseca E, Quintana M, Sarria-Estrada S, Santamarina E, Abraira L, Sueiras M, Thonon V, Álvarez-Sabin J, Toledo M, Rovira A.
Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography
J Neurol. 2022 Jul;269(7):3761-3769.
DOI: doi: 10.1007/s00415-022-11005-1
IF: 6.682

Sarria-Estrada S, Santamarina E, Quintana M, Pareto D, Sueiras M, Auger C, Toledo M, Rovira A.
Magnetic resonance imaging findings in focal-onset status epilepticus.
Eur J Neurol. 2022 Jan;29(1):3-11.
DOI: doi: 10.1111/ene.15065
IF: 6.281

Villanueva V, D'Souza W, Goji H, Kim DW, Liguori C, McMurray R, Najm I, Santamarina E, Steinhoff BJ, Vlasov P, Wu T, Trinka E
PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice
J Neurol. 2022 Apr;269(4):1957-1977
DOI: doi: 10.1007/s00415-021-10751-y
IF: 6.682

Sander JW, Rosenfeld WE, Halford JJ, Steinhoff BJ, Biton V, Toledo M.
Long-term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program.
Epilepsia. 2022 Jan;63(1):139-149
DOI: doi: 10.1111/epi.17134
IF: 6.740

Fonseca E, Quintana M, Seijo-Raposo I, Ortiz de Zárate Z, Abraira L, Santamarina E, Álvarez-Sabin J, Toledo M
Interictal brain activity changes in temporal lobe epilepsy: A quantitative electroencephalogram analysis
Acta Neurol Scand. 2022 Feb;145(2):239-248.
DOI: doi: 10.1111/ane.13543
IF: 3.915

Estudio de biomarcadores relacionados con epilepsia en la hemorragia subaracnoidea
Principal Investigator: Laura Abraira del Fresno
Agency: Eugenio Rodríguez Pascual
Funding: 24,990 €
Period: 2022-2023

Uso de marcadores en la detección de crisis epilépticas de mal pronóstico
Principal Investigator: Estevo Santamarina Pérez
Agency: Instituto de Salud Carlos III
Funding: 73,810€
Period: 2020-2024

Study of the mechanisms within the acute phase of stroke that enhance the development of epilepsy
Principal Investigator: José Alvarez Sabín
Agency: Fundació Marató TV3
Funding: 146,034.29€
Period: 2018-2022

Plataforma personalitzada per l’anàlisi de fàrmacs antiepilèptics
Principal Investigator: Miguel Chillón
Agency: AGAUR
Funding: 20,000€
Period: 2022-2023

Detección precoz del deterioro cognitivo en pacientes con epilepsia de reciente diagnóstico
Principal Investigator: Elena Fonseca Hernández
Agency: Aula Vall d'Hebron
Funding: 35,000€
Period: 2022-2023