During 2022, our group successfully transplanted retinal cells in the retina of animal models as a regenerative approach, allowing us to obtain funding to study, at the cellular level, retinal neuronal responses through calcium dynamics using a light-sheet microscope to create retinal volumetric connectivity maps, in collaboration with ICFO and PIC. Moreover, we developed human stem cell-derived retinal organoids as a disease model, as a drug screening platform, and as a cell source for cell therapy. These procedures and materials were patented in the USA. This preliminary research led to an ISCIII-funded project to study retinitis pigmentosa and develop novel gene therapies. We collaborate with several groups within the RICORS network in a common scientific program in the area of “ocular inflammatory diseases”, to advance the field of Personalized Medicine. The main goal is to standardize biomarkers and intended uses, such as diagnostic, prognostic, and therapeutic management.
eCOREs
