In 2022, our main research areas included the use of MRI in different neurological disorders, such as multiple sclerosis (MS), epilepsy, migraine, Parkinson disease, and neurooncology. We have worked on the application of virtual brain to study the relationship between structural and functional connectivity and its role in development of disability and cognitive impairment in MS. We have also worked in the automated detection of optic nerve lesions in MS by means of a 3D convolutional neural network, and in semiautomated approaches to measure the integrity of the optic nerve or the optic chiasm. In collaboration with TensorMedical, we have continued the evaluation of an automated tool for the detection of new MS lesions in brain images obtained from different MR systems with different field strength and with different acquisition parameters. We have developed an approach to estimate a map of brain veins from MRI images and applied to subjects with migraine and healthy controls.

Group Leader
Alex Rovira Cañellas

Principal Investigator (PI)
Alex Rovira Cañellas, Deborah Pareto Onghena

Carlos Tortajada Bustelo, Cristina Auger Acosta, Juli Alonso Farré, Francesc Xavier Aymerich Martínez, Silvana Isabel Sarria Estrada, Gerard Martí Juan, Sofía Sceppacuercia, Margareta Clarke

Lab Technicians
Juan Francisco Corral Gámez, Manel Alberich Jordà

Nursing and Technical Staff
Elena Beatriz Huerga Nuñez, Ana María Nieto Montoya










Sarria-Estrada S, Santamarina E, Quintana M, Pareto D, Sueiras M, Auger C, Toledo M, Rovira A
Magnetic resonance imaging findings in focal-onset status epilepticus
Eur J Neurol. 2022 Jan; 29(1): 3-11
DOI: doi: 10.1111/ene.15065
IF: 6.288

Rovira À, Auger C
Routine Gadolinium Use for MRI Follow-Up of Multiple Sclerosis: Counterpoint-Gadolinium Should Not Always Be Used to Assess Disease Activity
AJR Am J Roentgenol. 2022 Jul; 219(1): 26-27
DOI: doi: 10.2214/AJR.21.27069
IF: 6.582

Rovira A, Corral JF, Auger C, Valverde S, Vidal-Jordana A, Oliver A, de Barros A, Ng Wong YK, Tintoré M, Pareto D, Aymerich FX, Montalban X, Lladó X, Alonso J
Assessment of automatic decision-support systems for detecting active T2 lesions in multiple sclerosis patients
Mult Scler. 2022 Jul; 28(8): 1209-1218.
DOI: doi: 10.1177/13524585211061339
IF: 5.855

Martí-Juan G, Frías M, Garcia-Vidal A, Vidal-Jordana A, Alberich M, Calderon W, Piella G, Camara O, Montalban X, Sastre-Garriga J, Rovira À, Pareto D
Detection of lesions in the optic nerve with magnetic resonance imaging using a 3D convolutional neural network
Neuroimage Clin. 2022; 36: 103187.
DOI: doi: 10.1016/j.nicl.2022.103187
IF: 4.891

Aymerich FX, Auger C, Alonso J, Barros A, Clarke MA, Mora J, Arrambide G, Corral JF, Andrino A, Sastre-Garriga J, Rovira A
Assessment of 2D conventional and synthetic MRI in multiple sclerosis
Neuroradiology. 2022 Dec; 64(12): 2315-2322.
DOI: doi: 10.1007/s00234-022-02973-2
IF: 2.995

TReatment And VISual Recovery in Optic Neuritis – The TRAVIS study
Principal Investigator: Jaume Sastre-Garriga, Alex Rovira Cañellas
Agency: Instituto de Salud Carlos III
Funding: 96,800 €
Period: 2020-2022

Structural-functional spinal characterization by magnetic resonance imaging. Application in multiple sclerosis
Principal Investigator: Deborah Pareto Onghena
Agency: Instituto de Salud Carlos III
Funding: 37,510 €
Period: 2019-2023

The Virtual Brain: generative whole-brain models in Multiple Sclerosis
Principal Investigator: Deborah Pareto Onghena
Funding: 55,000 €
Period: 2021-2022