This year we expanded our research in transplant immunology and glomerular diseases by having been awarded with new national and European grants. In transplantation, we will investigate a common pan-transcriptional signature in peripheral blood across different solid organ transplants undergoing acute graft rejection. In new RCT, we will assess the impact of different immunosuppression withdrawal strategies on anti-HLA alloimmune sensitization after graft loss. Also, two new studies will focus on the immune biology of CMV and BK virus. Thanks to a new grant, we will carry on our researc on the biological bases of autoreactive vasculitis. Another important research area of our group is the study of the molecular basis of AKI driven by different insults, a project that is endorsed by a European grant. The group is progressively growing and unconditionally committed to improve the quality of life of patients suffering from different kidney diseases.

Group Leader
Oriol Bestard Matamoros, Maria José Soler Romeo

Principal Investigator (PI)
Francesc Moreso, Concepció Jacobs, Maria Meneghini, Elena Crespo

Researchers
Joana Sellarés, Irina Torres, Manel Perelló, Irene Agraz, Sheila Bermejo, Antonieta Azancot, Natàlia Ramos, Ander Vergara

PhD Students
Mónica Bolufe, Ignacio Cidraque, Marina López, Nestor Toapanta, Alba Torija, Laura Donadeu, Irene Martinez, Natalia Ramos

Lab Technicians
Núria Bolaños, Mariona Juvé, Pamela Domínguez, Carme Llorens

Nursing and Technical Staff
Oreto Prat Canet, Emma Pardo de los Santos, Fiona Robert, Carlota Medina, Valme Rodríguez, Rosa Pérez

72

PUBLICATIONS

72.2%

%Q1

523

IMPACT FACTOR

7.26

AVERAGE IMPACT FACTOR

SELECTED ARTICLES

Favà, A.; Donadeu, L.; Jouve, T.; Gonzalez-Costello, J.; Lladó, L.; Santana, C.; Toapanta, N.; Lopez, M.; Pernin, V.; Facundo, C.; Cabañas, N.S.; Thaunat, O.; Crespo, M.; Llinàs, L.; Revuelta, I.; Sabé, N.; Rombauts, A.; Calatayud, L.; Ardanuy, C.; Esperalba, J.; Fernandez, C.; Lozano, J.J.; Preyer, R.; Strecker, K.; Couceiro, C.; García-Romero, E.; Cachero, A.; Meneghini, M.; Torija, A.; Le Quintrec, M.; Melilli, E.; Cruzado, J.M.; Polo, C.; Moreso, F.; Crespo, E.; Bestard, O.
A comprehensive assessment of long-term SARS-CoV-2-specific immune memory in convalescent COVID-19 solid organ transplant recipients
Kidney International 2022; S0085-2538(22)00029-1
DOI: doi: 10.1016/j.kint.2021.12.029
IF: 18.998

Crespo, E.; Vidal-Alabró, A.; Jouve, T.; Fontova, P.; Stein, M.; Mocka, S.; Meneghini, M.; Sefrin, A.; Hruba, P.; Gomà, M.; Torija, A.; Favà, A.; Cruzado, J.M.; Melilli, E.; Moreso, F.; Viklicky, O.; Bemelman, F.; Reinke, P.; Grinyó, J.M.; Lloberas, N.; Bestard, O.
Tacrolimus CYP3A single nucleotide polymorphisms (SNPs) and preformed T and Bcell alloimmune memory improve current pretransplant rejection-risk stratification in kidney Transplantation
Frontiers in Immunology 2022; 13: 869554
DOI: doi: 10.3389/fimmu.2022.869554
IF: 8.787

García-Carro, C.; Bolufer, M.; Bury, R.; Castañeda, Z.; Muñoz, E.; Felip, E.; Lorente, D.; Carreras, M.J.; Gabaldon, A.; Agraz, I.; Serón, D.; Soler, M.J.
Acute kidney injury as a risk factor for mortality in oncological patients receiving checkpoint inhibitors
Nephrology, Dialysis & Transplantation 2022; 37 (5): 887-894
DOI: doi: 10.1093/ndt/gfab034
IF: 7.186

Pernin, V.; Meneghini, M.; Torija, A.; Jouve, T.; Del Bello, A.; Sanz-Muñoz, I.; Eiros, J.M.; Donadeu, L.; Polo, C.; Morandeira, F.; Navarro, S.; Masuet, C.; Favà, A.; LeQuintrec, M.; Kamar, N.; Crespo, E.; Bestard, O.
Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept
Frontiers in Immunology 2022; 13: 918887
DOI: doi: 10.3389/fimmu.2022.918887
IF: 8.787

Meneghini M, Perona A, Crespo E, Bemelman F, Reinke P, Viklicky O, Giral M, Palou E, Torija A, Donadeu L, Melilli E, Zuñiga J, Sefrin A, Lachmann N, Hu L, Hruba P, Guillot-Gueguen C, Brouard S, Grinyo J, Bestard O.
On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes
Frontiers in Immunology 2022; 13: 924825
DOI: doi: 10.3389/fimmu.2022.924825
IF: 8.787

UNRAVELLING THE PROTECTIVE PATHWAYS OF THE SGLT2I AND GLP-1RA IN DIABETIC KIDNEY DISEASE: ROLE OF THE MAP17 AND D-AKAP-2 SCAFFOLDER PROTEINS IN DB/DB MICE AND IN HUMAN KIDNEY ORGANOIDS
Principal Investigator: María José Soler Romeo
Agency: Instituto de Salud Carlos III
Funding: 122,210 €
Period: 2022-2024

AGORA, Algorithm of graft outcome in renal allograftransplantation
Principal Investigator: Oriol Bestard Matamoros
Agency: European Comission (ERAP PerMed) & ISCIII
Funding: 174.998,00 €
Period: 2022-2025

HORUS, Casting light on HOst-cytomegaloviRUs interaction in Solid organ transplantation
Principal Investigator: Oriol Bestard Matamoros
Agency: European Comission
Funding: 451,700 €
Period: 2022-2027

THE EUROPEAN TRANSPLANTATION AND INNOVATION CONSORTIUM FOR RISK STRATIFICATION IN KIDNEY TRANSPLANT PATIENTS
Principal Investigator: Oriol Bestard Matamoros
Agency: European Union
Funding: 902.892,00 €
Period: 2018-2022

MECANISMOS Y DIANAS TERAPEÚTICAS DE LA RESPUESTA INMUNOLÓGICA HUMORAL DE MEMORIA FACILITANDO EL RECHAZO DEL INJERTO EN EL TRASPLANTE RENAL (PROYECTO COMBAT)
Principal Investigator: Oriol Bestard Matamoros
Agency: Instituto de Salud Carlos III
Funding: 209.632,00 €
Period: 2020-2022