We aim to understand the role of the host immune system in response to infections in children addressing both infectious and immunological sides. This year the group described several genetic diseases causing viral infections (e.g, enterovirus meningoencephalitis, severe COVID-19), has elucidated the appropriate antifungal doses to treat invasive fungal infections and has defined the risk of progressive neurological disorders in children with Zika infected mothers. The group has increased the amount and quality of its scientific output using a multidisciplinary approach that promotes translational research focused on improving patients’ quality of life. Several national and international grants and prizes have recognized this value-based approach. Our research is currently developed in the context of several national (RITIP, RECLIP) and international initiatives (EmprEMA, COVIDHGE, JMF) and with active participation of patients and their families allowing a greater scientific outreach

Group Leader
Pere Soler Palacín

Principal Investigator (PI)
Maria Espiau Guarner, Antoni Soriano Arandes

Jacques Rivière, Andrea Martin Nalda, Natalia Mendoza Palomar, Susana Melendo Pérez, Antoinette Frick, Jorgina Vila Soler, Núria Worner Tomasa, Aurora Fernández Polo, Berta Fernández Ledesma, Marina Garcia Prat, Laura Batlle Massó

PhD Students
Alba Parra Martínez

Nursing and Technical Staff
Andrea Beneyto Dobón, Sonia Galindo Maycas, Claudia Broto Cortés, Laura López Seguer, Sonia Rodríguez Tello, Stephany Zelada Márquez, Miriam González Amores










Haimel M, Pazmandi J, Heredia RJ, Dmytrus J, Bal SK, Zoghi S, van Daele P, Briggs TA, Wouters C, Bader-Meunier B, Aeschlimann FA, Caorsi R, Eleftheriou D, Hoppenreijs E, Salzer E, Bakhtiar S, Derfalvi B, Saettini F, Kusters MAA, Elfeky R, Truck J, Riviere JG, van der Burg M, Gattorno M, Seidel MG, Burns S, Warnatz K, Hauck F, Brogan P, Gilmour KC, Schuetz C, Simon A, Bock C, Hambleton S, de Vries E, Robinson P, van Gijn M, Boztug K
Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.
J Allergy Clin Immunol. 2022 Jan;149(1):369-378. Epub 2021 May 12.
DOI: doi: 10.1016/j.jaci.2021.04.033.
IF: 14.29

Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Clin Infect Dis. 2022 Aug 25;75(2):248-259.
DOI: doi: 10.1093/cid/ciab928.
IF: 21.00

Deya-Martinez A, Riviere JG, Roxo-Junior P, Ramakers J, Bloomfield M, Guisado Hernandez P, Blanco Lobo P, Abu Jamra SR, Esteve-Sole A, Kanderova V, Garcia-Garcia A, Lopez-Corbeto M, Martinez Pomar N, Martin-Nalda A, Alsina L, Neth O, Olbrich P
Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain of Function (GOF) Mutations-10 Children and Review of the Literature.
J Clin Immunol. 2022 Jul;42(5):1071-1082. Epub 2022 Apr 29.
DOI: doi: 10.1007/s10875-022-01257-x.
IF: 8.54

Davalos V, Garcia-Prieto CA, Ferrer G, Aguilera-Albesa S, Valencia-Ramos J, Rodriguez-Palmero A, Ruiz M, Planas-Serra L, Jordan I, Alegria I, Flores-Perez P, Cantarin V, Fumado V, Viadero MT, Rodrigo C, Mendez-Hernandez M, Lopez-Granados E, Colobran R, Riviere JG, Soler-Palacin P, Pujol A, Esteller M
Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study.
EClinicalMedicine. 2022 Jun 25;50:101515. eCollection 2022 Aug.
DOI: doi: 10.1016/j.eclinm.2022.101515.
IF: 17.03

Buonsenso D, Perramon A, Catala M, Torres JP, Camacho-Moreno G, Rojas-Solano M, Ulloa-Gutierrez R, Camacho-Badilla K, Perez-Corrales C, Cotugno N, Yamazaki-Nakashimada, Estripeaut D, Buddingh EP, von Asmuth E, van Rossum AMC, Soler-Palacin P, Riviere JG, Prats C, Pino R, Paredes-Carmona F, Visa-Rene N, Garcia-Salido A, Martinez-Mejias A, Soriano-Arandes A
Multisystemic Inflammatory Syndrome in Children in Western Countries: Decreasing Incidence as the Pandemic Progresses?: An Observational Multicenter International Cross-sectional Study.
Pediatr Infect Dis J. 2022 Sep 12.
DOI: doi: 10.1097/INF.0000000000003713.
IF: 3.81

RBDCOV: RBD Dimer recombinant protein vaccine against SARSCoV2.
Principal Investigator: Pere Soler Palacin
Agency: European Comission H2020
Funding: 395,000 €
Period: 2021-2026

RECOMB: Stem-cell based gene therapy for recombination deficient SCID.
Principal Investigator: Pere Soler Palacin
Agency: European Comission H2020
Funding: 57,500 €
Period: 2018-2023

UNDINE: The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalized medicine.
Principal Investigator: Pere Soler Palacin
Agency: European Comission H2020
Funding: 312,525 €
Period: 2022-2027

SARS-CoV-2 and other respiratory viruses in childhood: different approaches to define predictive models for their diagnosis and epidemiological evolution.
Principal Investigator: Antoni Soriano Arandes
Agency: Fundació La Marató TV3
Funding: 299,950 €
Period: 2021-2024

Phase IV, randomized, open label, parallel groups clinical trial for evaluating the early Stop of antibiotic Treatment in febrile neutropenic Oncohaematological Paediatric patients (eSTOP-study).
Principal Investigator: Pere Soler Palacin
Agency: Instituto Carlos III (ISCIII)
Funding: 135,520 €
Period: 2020-2023

PIDCAP (Early detection of primary immunodeficiencies in Primary Care)
Priority Number: 1908021605053
Priority Date: 29/07/2019
Applicants: VHIR (50% Pere Soler Palacin, 50% Jacques Riviere)

Play PROA (Training by gamification in pediatric antimicrobial stewardship programs).
Priority Number: 1907251526961
Priority Date: 05/08/2019
Applicants: VHIR (Pere Soler Palacín, Aurora Fernández Polo, Susana Melendo Pérez)