The main research lines in 2022 have been: i) cerium oxide nanoparticles as antioxidant, anti-inflammatory and immunomodulator agents, ii) the use of gold nanoparticle protein conjugates to direct biological responses, and iii) developing ionizable lipid nanoparticles as universal vehicle for advanced drug delivery (proteins, genetic material, nanoparticles). Regarding i) we have followed works in ophthalmology and neurology, starting on cardiology, and planning for transplants, all in collaboration with vhir and HdVH departments. We have also dedicated efforts to the transfer of our collyrium patent to a Swiss commercial partner. On the second aspect, we have been preparing gold nanoparticles virus like particles to be tested soon in its capacity to safely induce strong and lasting immune memory. On the third aspect, our newest research line, we have successfully encapsulated and transfected cells in vitro continuing work on mRNA transfection for time limited CAR-T cell therapy.

Group Leader
Victor Franco Puntes

Principal Investigator (PI)
Joan Comenge

PhD Students
Lena Montana Ernst, Joana Ramis Garcia, Ramon Gonzalez Rioja










V Puntes, J Oliveras, L Marcon, N Bastus
Functionalization of Graphene Nanostructures with Inorganic Nanoparticles and Their Use for the Removal of Pharmaceutical Pollutants in Water.
Frontiers in Chemical Engineering 2022, 17,431
DOI: doi: 10.3389/fceng.2022.1084035
IF: 4.24

Galyamin, D.; Ernst, L. M.; Fitó-Parera, A.; Mira-Vidal, G.; Bastús, N. G.; Sabaté, N.; puntes, v
Nanoceria dissolution at acidic pH by breaking off the catalytic loop.
Nanoscale, 2022,14, 14223-14230
DOI: doi: 10.1039/d2nr03586c
IF: 8.599

LM Ernst, V Puntes
How Does Immunomodulatory Nanoceria Work? ROS and Immunometabolism
Frontiers Immunology, 2022 Mar 17;13:750175
DOI: doi: 10.3389/fimmu.2022.750175
IF: 8.786

Xu Han, Gerard Boix, Mateusz Balcerzak, Oscar Hernando Moriones, Mary Cano‐Sarabia, Pilar Cortés, Neus Bastús, Victor Puntes, Montserrat Llagostera, Inhar Imaz, Daniel Maspoch
Antibacterial Films Based on MOF Composites that Release Iodine Passively or Upon Triggering by Near‐Infrared Light
Advanced Functional Materials, 2022 , 32, (19) , 2112902
DOI: doi: 10.1002/adfm.202112902
IF: 18.808

Barbero, F.; Michelini, S.; Moriones, O. H.; Patarroyo, J.; Rosell, J.; F. Gusta, M.; Vitali, M.; Martín, L.; Canals, F.; Duschl, A., Jutta Horejs-Hoeck , Laura Mondragó,, Neus G Bastús, V.Puntes
Role of Common Cell Culture Media Supplements on Citrate-Stabilized Gold Nanoparticle Protein Corona Formation, Aggregation State, and the Consequent Impact on Cellular Uptake
Bioconjugate Chemistry 2022, 33 (8), 1505-1514
DOI: doi: 10.1021/acs.bioconjchem.2c00232
IF: 4.349

Utilidad de las nanopartículas de óxido de cerio en enfermedades hepáticas e intestinales consecuencia de una desregulación metabólica y asistencia a la regeneración hepática.
Principal Investigator: Victor Puntes
Agency: ISCIII
Funding: 68,252 €
Period: 2022

Mesoporous silica wrapped nanoparticle composite material, preparation method thereof, and use thereof
Priority Number: US Patent App. 17/847,142, 2022
Priority Date: 6/10/2022
Applicants: Wuyi University, CH