Our work is focused in the characterization of physiological roles of the death receptor antagonist, FAIM-L. We had previously evidenced its interaction in neurons with XIAP and Siva-1, confirming that FAIM-L is involved in neuronal plasticity processes by modulating caspases activity. We have characterized an interaction in vitro and in vivo of FAIM-L with tau, a key protein in Alzheimer’s disease (AD), and how FAIM-L is post-translationally modifying tau protein, thus showing the relevance of FAIM-L in the development of tauopathies and neurodegenerative processes. In addition, our results show a key role for FAIM-L in retinal homeostasis, by controlling glial response, ubiquitinated protein aggregation, vascular leakage, and photoreceptor signaling and survival. We are also developing new tools to better characterize FAIM-L expression and to modulate its levels in different animal models of AD, with the aim to better knowing its role in neuron physiology and neurodegeneration.

Group Leader
Joan Xavier Comella Carnicé

Montserrat Solé Piñol

PhD Students
Raquel Badillos Rodríguez, Mireia Turch Anguera, Anna Martínez Sirés

Lab Technicians
Joaquín López Soriano










Coccia E, Solé M & Comella JX
FAIM-L – SIVA-1: two modulators of XIAP in non-apoptotic caspase function
Frontiers in Cell and Developmental Biology-Signaling 2022, 9:826037
DOI: doi: 10.3389/fcell.2021.826037
IF: 6.081

Papel del antagonista de receptores de muerte, FAIM-L, en la progresión de la enfermedad de Alzheimer
Principal Investigator: Joan X. Comella
Agency: Ministerio de Ciencia e Innovación
Funding: 180,000 €
Period: 2020-2023

Retinal and cognitive dysfunction in type 2 diabetes: unravelling the common pathways and identification of patients at risk of dementia (RECOGNISED)
Principal Investigator: Rafael Simó
Agency: European Union
Funding: 5,998,272 €
Period: 2020-2023